When mapping the layouts, if there is no screen share happening they are labeled 1 to 6 accordingly. When a screen share is happening "Spotlight" becomes layout 1 and all other layouts shift up one (2 - 7). If your using your hotkeys, you will now be mapping to the incorrect layout. This is particularly a problem if you are trying to use a tool like a Stream Deck.
I would suggets that the "Spotlight" layout get added to the end of the sequence. (7) This would keep consistency with all other layouts regardless if Spotlight is enabled or not.